Dr. Andy Brown’s (Treat Williams) seemingly perfect life was shattered when his wife, Julie, was killed in a tragic car accident. Prior to the accident, Andy was a world-famous neurosurgeon who often put his career before his family life. Now, Andy must single-handedly raise his two children, Ephram (Gregory Smith) and Delia (Vivien Cardone). In order to do so, Andy moved his family from New York City to the quiet, yet charming town of Everwood, Colorado.
In Everwood, Andy opened a free clinic, much to the dismay of most of the citizens. However, Edna Harper (Debra Mooney) saw something in Andy that no one else saw and applied to be Andy’s nurse and office manager. Andy was also well received by Irv (John Beasley), Edna’s husband, and his new next-door neighbor, Nina Feeney (Stephanie Niznik). But along with the warm welcomes came the less than pleased individuals, including Dr. Harold Abbott (Tom Amandes), who forbade his wife Rose (Merrilyn Gann), and children, Amy (Emily VanCamp) and Bright (Chris Pratt) to be around Andy or his children.
But regardless of such warnings, Amy quickly befriended Ephram, who instantly fell in love with her. Over the years, the two have formed a friendship, and for awhile, they even managed to be more than just friends. Ephram also formed an unlikely bond with Bright, and the two remain close friends, and recently have become roommates. Over time, Harold warmed up to Andy, and the two are now partners. However, despite the picturesque appearance of Everwood, the residents are faced with hardships and drama, including cancer, drug addiction, secret affairs, and tragic deaths all while trying to live a quiet life in a small town.